Key result
Radiotherapy in breast cancer patients significantly increased early cardiac index (3.21 to 3.75 l/min/m2) and stroke volume index, likely due to radiodermatitis rather than cardiac deterioration.
Why the study?
The study was conducted to determine the early effects of radiotherapy on cardiac function in patients with breast cancer using impedance cardiography.
Does radiotherapy affect early hemodynamic parameters measured by impedance cardiography in breast cancer patients?
Observational
Does radiotherapy affect early hemodynamic parameters measured by impedance cardiography in breast cancer patients?
Absolute Event Rate: 3.75% vs 3.21%
Radiotherapy in breast cancer patients causes early increases in cardiac index, stroke volume index, and thoracic fluid volume, which may be related to radiodermatitis rather than early deterioration in heart function.
Early hemodynamic increases after radiotherapy may reflect radiodermatitis rather than dysfunction; hypothesis-generating for impedance cardiography in breast cancer.
This study was conducted to determine the effect of radiotherapy (RT) on heart functions in the early period in patients with breast cancer. The hemodynamic parameters showing heart functions of patients were recorded by impedance cardiography (ICG), a noninvasive method for monitoring heart function before and after RT. Some hemodynamic parameters of patients compared to before RT increased significantly after RT. Hemodynamic parameters that increased significantly following RT, compared with baseline: cardiac index (CI) (l/min/m2), before radiotherapy 3.21 ± 0.71, after radiotherapy 3.75 ± 1.01; stroke volume index (SVI) (ml/min/m2), before radiotherapy 37.32 ± 8.87, after radiotherapy 44.49 ± 10.85; thoracic fluid volume (TFC) (kohm−1), before radiotherapy 35.43 ± 7.70, after radiotherapy 39.52 ± 10.37. The findings suggested that short-term effects of RT on hemodynamic parameters in breast cancer patients were not due to deterioration in heart functions, but could be due to radiodermatitis, which can be seen in patients up to 42 days after RT. As a part of the treatment plan of patients receiving RT, it may be recommended to determine changes in heart functions with ICG and to plan new studies in which patients will be followed for a longer period.
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Uğraş et al. (2025) conducted an observational in Breast cancer. Radiotherapy vs. Baseline (before radiotherapy) was evaluated on Cardiac index (l/min/m2). Radiotherapy in breast cancer patients significantly increased early cardiac index (3.21 to 3.75 l/min/m2) and stroke volume index, likely due to radiodermatitis rather than cardiac deterioration.
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