Why the study?
Does ouabain and vagal stimulation affect sinus nodal function in conscious dogs?
Population
Instrumented conscious dogs
Design
Preclinical
Authors
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Hypothesis-generating for vagally mediated sinus node effects in dogs; leaves open translation to human arrhythmias.
Does ouabain and vagal stimulation affect sinus nodal function in conscious dogs?
The effects of ouabain on sinus nodal function in conscious dogs are similar to vagal stimulation and are abolished by atropine, suggesting they are vagally mediated.
Hariman et al. (1982) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: