Key result
Automated office blood pressure demonstrated a similar predictive ability for microalbuminuria as 24-h ambulatory blood pressure (AUC for SBP 0.819 vs 0.830; P<0.001 for both).
Why the study?
Is automated office blood pressure (AOBP) as closely associated with urine albumin excretion as 24-h ambulatory blood pressure (ABP) in hypertensive subjects?
Cross-Sectional (n=162)
Is automated office blood pressure (AOBP) as closely associated with urine albumin excretion as 24-h ambulatory blood pressure (ABP) in hypertensive subjects?
Automated office blood pressure correlates similarly with microalbuminuria as 24-h ambulatory blood pressure, supporting its use as an indicator of early renal impairment in clinical settings.
BACKGROUND: We aimed to investigate the association between automated office blood pressure (AOBP) readings and urine albumin excretion (UAE), and to assess if this association is as close as that between 24-h ambulatory blood pressure (ABP) and UAE. A strong association would suggest that AOBP may serve as an indicator of early renal impairment. METHODS: In a sample of 162 hypertensives, we compared AOBP with ABP measurements and their associations with UAE in two consecutive 24-h urine collections measured by an immunoturbidimetric assay. Microalbuminuria was defined as UAE of 30-300 mg/24 h. RESULTS: The age of the subjects was 53 ± 13 (mean ± s.d.) years. Twenty-two were microalbuminuric. In those, AOBP and 24-h ABP were higher than in the normoalbuminuric subjects: 152 ± 19 and 147 ± 20 vs. 138 ± 15 and 130 ± 11 mm Hg for systolic blood pressure (SBP), and 97 ± 15 and 92 ± 14 vs. 86 ± 10 and 82 ± 8 mm Hg for diastolic blood pressure (DBP) (P < 0.001). Correlations between AOBP and 24-h ABP with log-transformed urine albumin were 0.30 (P < 0.001) and 0.43 (P < 0.001) for SBP and 0.27 (P < 0.001) and 0.33 (P < 0.001) for DBP. Adjusting for age, sex, body mass index, and estimated glomerular filtration rate, both AOBP and 24-h ABP were independently associated with urine albumin (P < 0.001 for both associations). Receiver operating characteristics curve analysis showed a similar predictive ability for microalbuminuria for AOBP and for 24-h ABP (area under the curve: 0.819 (P < 0.001) for SBP, 0.836 (P < 0.001) for DBP vs. 0.830 (P < 0.001) for SBP and 0.845 (P < 0.001) for DBP). CONCLUSIONS: In this study, microalbuminuria correlated similarly with high-quality AOBP and ABP readings, further supporting the use of AOBP in the clinical setting.
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Andreadis et al. (2012) conducted a cross-sectional in Hypertension (n=162). Automated office blood pressure (AOBP) vs. 24-h ambulatory blood pressure (ABP) was evaluated on Predictive ability for microalbuminuria (area under the curve) (p=<0.001). Automated office blood pressure demonstrated a similar predictive ability for microalbuminuria as 24-h ambulatory blood pressure (AUC for SBP 0.819 vs 0.830; P<0.001 for both).
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