Key result
Elevated soluble gp130 (fifth quintile) was not associated with the primary composite endpoint (HR 1.12; 95% CI 0.84-1.50; P=0.44), but predicted higher all-cause and cardiovascular mortality.
Why the study?
Does elevated soluble gp130 predict fatal outcomes in elderly patients with ischemic heart failure?
Population
1,452 patients with heart failure, aged ≥60 years, in New York Heart Association classes II to IV, with…
Comparison
Elevated soluble glycoprotein 130 levels. vs Lower soluble gp130 levels.
Design
Cohort
Authors
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Supports further investigation of soluble gp130 for mortality risk stratification; leaves open its clinical utility in elderly ischemic HF.
Cohort (n=1,452)
Yes
Does elevated soluble gp130 predict fatal outcomes in elderly patients with ischemic heart failure?
Hazard Ratio: 1.12 (95% CI 0.84–1.5)
p-value: p=0.44
Marked elevations in soluble gp130 independently predict all-cause mortality, cardiovascular mortality, and death from worsening heart failure in elderly patients with ischemic heart failure.
Askevold et al. (2012) conducted a cohort in Chronic Heart Failure (n=1,452). Elevated soluble gp130 (fifth quintile) vs. All lower quintiles was evaluated on Composite of death from cardiovascular causes, nonfatal myocardial infarction, and nonfatal stroke (HR 1.12, 95% CI 0.84-1.50, p=0.44). Elevated soluble gp130 (fifth quintile) was not associated with the primary composite endpoint (HR 1.12; 95% CI 0.84-1.50; P=0.44), but predicted higher all-cause and cardiovascular mortality.
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