Key result
The CC genotype of the -786T>C polymorphism of the eNOS gene was associated with a higher incidence of hemodynamic risk factors and vasoconstriction in young men, but not women, from the European North.
Why the study?
Does the -786T>C polymorphism of the eNOS gene affect hemodynamic and vascular risk factors for arterial hypertension in young healthy adults from the European North?
Cross-Sectional (n=286)
No
Does the -786T>C polymorphism of the eNOS gene affect hemodynamic and vascular risk factors for arterial hypertension in young healthy adults from the European North?
Answers are grounded in this paper and cite their sources.
The CC genotype of the -786T>C eNOS polymorphism is associated with endothelial dysfunction and exaggerated hemodynamic responses to exercise in young men from the European North, serving as a potential genetic predictor for arterial hypertension.
A variety of studies demonstrates the association between the -786T>C polymorphism of eNOS, nitric oxide (NO) level and different parameters of cardiovascular system (CVS). The majority of these studies includes middle-aged and elderly individuals with cardiovascular disorders (CVD), so it is difficult to evaluate the role of genotypes of -786T>C polymorphism of eNOS in arterial hypertension (AH). The aim of this study is to determine the association between -786T>C polymorphism of eNOS and hemodynamic and vascular risk factors of AH in young healthy adults from European North. Metods. 286 healthy young men and women constantly living in Arctic region were examined in this cross-sectional study. Genotyping of -786T>C polymorphism of eNOS, hemodynamic parameters before and after physical probe (peripheral resistance, arterial pressure, heart rate, pulse pressure etc.), NO and endothelin-1 (ET-1) plasma level, index NO/ET-1 were determined in this study. Statistical methods include Pearson x2 test. Results. The imbalance of vasoactive endothelial factors (which lead to vasoconstriction) and higher incidence of hemodynamic risk factors were revealed in young men with CC genotype. There is no association between CC genotype and NO, ET-1 level and hemodynamics in the group of young women. Conclusion. Genotype CC of -786T>C polymorphism of eNOS can be genetic predictor of AH for young men from European North but not for young women from European North.
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Bebyakova et al. (2018) conducted a cross-sectional in Healthy (risk of arterial hypertension) (n=286). -786T>C polymorphism of eNOS gene (CC genotype) vs. TT and TC genotypes was evaluated on Incidence of hemodynamic risk factors (hypertonic reaction to physical load) and imbalance of vasoactive endothelial factors (p=0.01). The CC genotype of the -786T>C polymorphism of the eNOS gene was associated with a higher incidence of hemodynamic risk factors and vasoconstriction in young men, but not women, from the European North.
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