Key result
Growth hormone administration in adults with growth hormone deficiency significantly improved anthropomorphic and cardiovascular parameters, including a reduction in LDL cholesterol (ES -1.09), but worsened diabetes markers.
Why the study?
Does growth hormone treatment improve anthropomorphic, cardiovascular, and diabetes parameters in adults with growth hormone deficiency?
Population
2231 adults with growth hormone deficiency
Comparison
Growth hormone (GH) treatment vs Placebo
Design
Meta-analysis, randomized clinical studies, blinded, placebo controlled
Authors
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GH replacement in GHD adults requires glycemic monitoring; confirms lipid and body-composition benefits with diabetes trade-off.
Meta-Analysis (n=2,231)
Blinded
Randomized
Does growth hormone treatment improve anthropomorphic, cardiovascular, and diabetes parameters in adults with growth hormone deficiency?
Standardized Mean Difference: -1.09 (95% CI -1.49–-0.7)
p-value: p=<0.0001
Growth hormone replacement in adults with growth hormone deficiency improves body composition and lipid profiles but worsens glycemic control.
Pastuszak et al. (2012) conducted a meta-analysis in Growth Hormone Deficiency (n=2,231). Growth Hormone vs. Placebo was evaluated on Low density lipoprotein (LDL) cholesterol (ES -1.09, 95% CI -1.49, -0.70, p=<0.0001). Growth hormone administration in adults with growth hormone deficiency significantly improved anthropomorphic and cardiovascular parameters, including a reduction in LDL cholesterol (ES -1.09), but worsened diabetes markers.
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