What question did this study set out to answer?

To comprehensively review the role of the Notch signaling pathway in osteogenesis, bone development, metabolism, and associated skeletal diseases, while exploring therapeutic implications.

February 22, 2025The FASEB JournalOpen Access

Notch signaling pathway in osteogenesis, bone development, metabolism, and diseases

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Authors

MDMuhammad DilawarZhejiang Sci-Tech University XYXuan YuZhejiang Sci-Tech University SLSisi LinZhejiang Sci-Tech University

Discussion

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Implication

Narrative review demonstrates the regulatory role of Notch signaling in bone homeostasis, suggesting novel therapeutic targets for skeletal disorders.

Key Points

To comprehensively review the role of the Notch signaling pathway in osteogenesis, bone development, metabolism, and associated skeletal diseases, while exploring therapeutic implications.
Literature synthesis examining five Notch ligands (JAG1, JAG2, DLL1, DLL3, DLL4), four receptors (Notch1–4), and intracellular domains (NICD1–4) in skeletal biology.
Review of molecular cross-talk between Notch and other signaling cascades, including Wnt/β-catenin, BMP, TGF-β, FGF, autophagy, and Hedgehog pathways.
Notch signaling components fundamentally regulate osteoblast differentiation and ossification during developmental and postnatal stages.
Dysregulation of Notch signaling directly contributes to skeletal disorders, including osteoporosis and osteoarthritis.
Modulating Notch pathway interactions with secondary cascades provides potential molecular targets for bone-targeted drug discovery.

Cite This Study

Dilawar et al. (2025) studied this question.

synapsesocial.com/papers/6a82fe6a88eff2bd7befdefa https://doi.org/10.1096/fj.202402545r

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February 22, 2025The FASEB JournalOpen Access

Notch signaling pathway in osteogenesis, bone development, metabolism, and diseases

View Full Paper

Ask AI

Bookmark

Authors

MDMuhammad DilawarZhejiang Sci-Tech University XYXuan YuZhejiang Sci-Tech University SLSisi LinZhejiang Sci-Tech University

Discussion

Member takes

Implication

Narrative review demonstrates the regulatory role of Notch signaling in bone homeostasis, suggesting novel therapeutic targets for skeletal disorders.

Key Points

To comprehensively review the role of the Notch signaling pathway in osteogenesis, bone development, metabolism, and associated skeletal diseases, while exploring therapeutic implications.
Literature synthesis examining five Notch ligands (JAG1, JAG2, DLL1, DLL3, DLL4), four receptors (Notch1–4), and intracellular domains (NICD1–4) in skeletal biology.
Review of molecular cross-talk between Notch and other signaling cascades, including Wnt/β-catenin, BMP, TGF-β, FGF, autophagy, and Hedgehog pathways.
Notch signaling components fundamentally regulate osteoblast differentiation and ossification during developmental and postnatal stages.
Dysregulation of Notch signaling directly contributes to skeletal disorders, including osteoporosis and osteoarthritis.
Modulating Notch pathway interactions with secondary cascades provides potential molecular targets for bone-targeted drug discovery.

Cite This Study

Dilawar et al. (2025) studied this question.

synapsesocial.com/papers/6a82fe6a88eff2bd7befdefa https://doi.org/10.1096/fj.202402545r

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