Key result
The combination of G/T eNOS, G/G Eln, C/C NPPB, and I/D ACE genotypes was significantly associated with decreased endothelium-dependent vasodilatation in children with type 1 diabetes (r=0.61, p<0.01).
Why the study?
Do specific genetic polymorphisms associate with reduced endothelium-dependent vasodilatation in children with type 1 diabetes mellitus?
Cross-Sectional (n=45)
No
Do specific genetic polymorphisms associate with reduced endothelium-dependent vasodilatation in children with type 1 diabetes mellitus?
Specific genetic polymorphisms in eNOS, Eln, NPPB, and ACE genes are associated with worse endothelial function in children with type 1 diabetes, potentially identifying a high-risk group for vascular complications.
Hypothesis-generating for genotype-based vascular risk stratification in pediatric type 1 diabetes; prospective validation required before clinical use.
We have studied the association with the level of the endothelium dependent vasodilatation (EDVD) among 11 single nucleotide polymorphisms (SNPs) of 10 genes in 45 children suffering from diabetes mellitus type 1. Following polymorphisms have been studied: G894→T of the eNOS exon 7 and Т-786→С of the eNOS promotor, А1266→G of the Eln exon 16, Т-381→C of the NPPB promotor, І of the ACE, Arg60→His of the LMP2, Met235→Thr of the AGT, A1166→C of the ATR1, C-1562→T of the MMP9, C-1306→T of the MMP2, and С-8→G of the PSMA6. It was shown that children with genotypes G/T by eNOS (G894→T), G/G by Eln (А1266→G), C/C by NPPB (Т-381→C) and І/D by ACE genes have lower EDVD (Р<0,05) than patients with others allelic variants of these genes, and this does not depend on duration of the disease, level of glicated hemoglobin and initial diameter of a humeral (brachial) artery. The combination of the above-stated genotypes influences most significantly on EDVD decrease (r=0,61; Р<0,01), comparing to each genotype separately.
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Pranik et al. (2015) conducted a cross-sectional in Type 1 diabetes mellitus (n=45). High-risk genotypes (G/T eNOS, G/G Eln, C/C NPPB, I/D ACE) vs. Other allelic variants was evaluated on Endothelium-dependent vasodilatation (EDVD) (r=0.61, p=<0.01). The combination of G/T eNOS, G/G Eln, C/C NPPB, and I/D ACE genotypes was significantly associated with decreased endothelium-dependent vasodilatation in children with type 1 diabetes (r=0.61, p<0.01).
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