Key result
The T/C (T786C) polymorphism in the eNOS gene was associated with metabolic syndrome including type 2 diabetes, whereas the ACE I/D polymorphism showed no association with diabetic nephropathy.
Observational
In Central European diabetic patients, the eNOS T786C polymorphism is linked to metabolic syndrome, while the ACE I/D polymorphism is not associated with diabetic nephropathy.
eNOS T786C may link to metabolic syndrome in diabetics; leaves open ACE I/D nephropathy role pending validation.
A considerable variability in the incidence and prevalence of diabetic nephropathy (DN) coheres with an important contribution of multigenetic predisposition in the development of DN. Some genes, which probably participate in the pathogenesis of diabetic nephropathy, also play a role in the regulation of blood pressure, familial hyperlipidemia, familial hypertension and other diseases of the cardiovascular system. We have examined the association of diabetic nephropathy, nephropathy of non-diabetic origin, hypertension and of type 2 diabetes itself with several genetic polymorphisms (the insertion/deletion polymorphism in the gene for angiotensin-converting enzyme, the G/T polymorphism in the glucose transporter 1 gene, the G/T (894) polymorphism and the T/C (−786) polymorphism in the eNOS gene in three groups of patients with diabetes mellitus: 1) patients without diabetic nephropathy (DM); 2) patients with DN; 3) patients with nephropathy of non-diabetic origin (NDRD). Angiotensin-converting enzyme is an important factor in a development of arterial hypertension, but in our groups of Central European diabetic patients the I/D polymorphism was not associated with diabetic nephropathy. Furthermore, we have confirmed that the T/C (T786C) polymorphism in the eNOS gene is associated with metabolic syndrome including type 2 diabetes.
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Demová et al. (2012) conducted an observational in Type 2 diabetes and diabetic nephropathy. Genetic polymorphisms (ACE I/D, GLUT1 G/T, eNOS G/T and T/C) vs. Different genotype groups was evaluated on Association of genetic polymorphisms with diabetic nephropathy and metabolic syndrome. The T/C (T786C) polymorphism in the eNOS gene was associated with metabolic syndrome including type 2 diabetes, whereas the ACE I/D polymorphism showed no association with diabetic nephropathy.
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