Key result
Adapting microscale equations to account for Debye layers and using homogenization techniques showed that standard assumptions about conductivity tensors in cardiac tissue are usually valid.
Why the study?
Deriving the bidomain equations for cardiac electrophysiology assumes electrical equilibrium in intracellular and extracellular spaces, neglecting disturbances in thin regions close to cell membranes known as Debye layers.
This computational study refines the mathematical modeling of cardiac electrophysiology by accounting for Debye layers and evaluating the validity of conductivity tensor assumptions.
Authors
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Standard conductivity assumptions hold in cardiac models after Debye adjustments; leaves open need for case-specific validation in pathology.
Jonathan Whiteley (2019) studied Cardiac electrophysiology. Mathematical modeling of bidomain equations was evaluated. Adapting microscale equations to account for Debye layers and using homogenization techniques showed that standard assumptions about conductivity tensors in cardiac tissue are usually valid.
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