The synthesis of [ 125 I]iodobuprenorphine is described. This compound has been used as a tracer molecule in the development of a new radioimmunoassay for buprenorphine. The parameters that effect the direct iodination of buprenorphine using sodium [ 127 I]iodide, in the presence of either chloramine‐T or Iodo‐Beads ® , were previously studied. The structure of iodobuprenorphine was confirmed by mass spectrometry.
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Debrabandere et al. (1992) studied this question.
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