Key result
Over-expression of soluble guanylate cyclase in human breast cancer cells induced apoptosis and growth inhibition in vitro, and reduced tumor incidence and growth rate in mouse xenografts.
Down-regulation of sGC via promoter methylation promotes breast cancer cell survival, and its restoration suppresses tumor growth in vitro and in vivo.
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sGC overexpression may inhibit breast tumors; hypothesis-generating from animal data only, requiring clinical trials.
Wen et al. (2015) studied Breast cancer (n=10). Over-expression of soluble guanylate cyclase (sGC) vs. Control vector was evaluated on Tumor incidence and growth rate in vivo, and cell proliferation/survival in vitro. Over-expression of soluble guanylate cyclase in human breast cancer cells induced apoptosis and growth inhibition in vitro, and reduced tumor incidence and growth rate in mouse xenografts.
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