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October 1, 1994AJP Heart and Circulatory Physiology

Rate-limiting steps in activation of cardiac Cl- current revealed by photolytic application of cAMP

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Population

Single myocytes obtained from guinea-pig ventricles

Design

Preclinical

Authors

YNYasuharu NakashimaKOKenji Ono

Discussion

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Overview

cAMP production and phosphorylation limit cardiac ICl speed; leaves open relevance to human electrophysiology or arrhythmias.

Structured PICO

P
Population
Single myocytes obtained from guinea-pig ventricles
I
Intervention
Photolytic application of caged cAMP (concentration jump technique) and rapid bath application of isoprenaline
O
Outcome
Activation kinetics and conductance of catecholamine-induced Cl- current (ICl)surrogate

Both the production of cAMP and reactions on multiple phosphorylation sites of the channel protein are major rate-limiting steps in cardiac ICl activation.

Cite This Study

Nakashima et al. (1994) studied this question.

synapsesocial.com/papers/6a82ff8f292d2964071f2460https://doi.org/10.1152/ajpheart.1994.267.4.h1514
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