Key result
In frog cardiac myocytes, beta-adrenergic stimulation of L-type calcium current exhibits a lag period attributed to a step associated with activation of adenylyl cyclase and cAMP accumulation.
Population
Frog cardiac myocytes
Design
Preclinical
Authors
Loading...
Hypothesis-generating for cAMP signaling kinetics; should not alter clinical beta-adrenergic management.
The lag period in beta-adrenergic stimulation of cardiac calcium current is primarily due to steps associated with adenylyl cyclase activation and cAMP accumulation.
Frace et al. (1993) studied this question. Isoproterenol and other caged compounds was evaluated on Activation kinetics of L-type calcium current (ICa). In frog cardiac myocytes, beta-adrenergic stimulation of L-type calcium current exhibits a lag period attributed to a step associated with activation of adenylyl cyclase and cAMP accumulation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: