Key result
Simultaneous measurement in frog ventricular myocytes revealed that cAMP transients are shorter than L-type Ca2+ current transients following isoprenaline application.
Simultaneous measurement of [cAMP]i and ICa in intact cardiac myocytes reveals that hydrolysis of cAMP by phosphodiesterases is not a rate-limiting step in the recovery of ICa from beta-adrenergic stimulation.
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Does not support changes to beta-adrenergic therapies; leaves open whether PDEs limit ICa recovery in mammalian myocytes.
Goaillard et al. (2001) studied this question. Isoprenaline (ISO) and Forskolin (FSK) vs. Basal/control level was evaluated on Intracellular cAMP concentration and L-type Ca2+ current. Simultaneous measurement in frog ventricular myocytes revealed that cAMP transients are shorter than L-type Ca2+ current transients following isoprenaline application.
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