August 1, 2003The Journal of Physiology

Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes

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Population

Frog ventricular myocytes

Comparison

Isoprenaline applied locally, alone or with PDE… vs Isoprenaline alone

Design

Preclinical

Authors

JJJonas JurevičiusLithuanian University of Health Sciences VSVytenis Arvydas SkeberdisLithuanian University of Health Sciences RFRodolphe FischmeisterElectrophysiology

Discussion

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Implication

PDE3/PDE4 inhibition may alter cAMP compartmentation in cardiomyocytes; leaves open translation to human heart failure.

Structured PICO

Population

Frog ventricular myocytes

Intervention

Isoprenaline (1 nM to 10 microM) applied locally, alone or with PDE inhibitors (IBMX 100 microM, milrinone 3 microM, Ro 20-1724 3 microM, okadaic acid 3 microM, or H89 1 microM)

Comparator

Isoprenaline alone

Outcome

Gradient of local vs. distant cAMP concentration (alpha) determined by local and distant responses of ICa,Lsurrogate

PDE3 and PDE4 subtypes play a major role in cAMP compartmentation in frog ventricular cells upon beta2-adrenergic stimulation, ensuring functional coupling of beta2-adrenergic receptors with nearby Ca2+ channels.

Cite This Study

Jurevičius et al. (2003) studied this question.

synapsesocial.com/papers/6a834459d4f0d3e447933974 https://doi.org/10.1111/j.1469-7793.2003.00239.x

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Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider