Key result
PDE3A isoforms comprise the majority of cAMP hydrolytic activity in microsomal fractions of human myocardium, while their contribution in cytosolic fractions depends on cAMP and calcium levels.
The contribution of PDE3 isoforms to cAMP hydrolysis in human myocardium is highly dependent on intracellular calcium and cAMP levels, which are altered in heart failure.
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Hypothesis-generating for PDE3A-selective inhibition in HF; does not yet support changes in clinical practice.
Hambleton et al. (2005) studied this question. PDE3 isoforms (PDE3A-136, PDE3A-118, PDE3A-94) was evaluated on cAMP hydrolytic activity. PDE3A isoforms comprise the majority of cAMP hydrolytic activity in microsomal fractions of human myocardium, while their contribution in cytosolic fractions depends on cAMP and calcium levels.
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