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August 12, 2002Proceedings of the National Academy of SciencesOpen Access

Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes

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Population

Cardiac myocytes

Comparison

Activation of PKG I by NO/cGMP and adenoviral… vs Untreated cardiac myocytes or those expressing…

Design

Preclinical

Authors

BFBeate FiedlerSLSuzanne M. LohmannASAlbert Smolenski

Discussion

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Overview

May suppress hypertrophy via calcineurin-NFAT blockade in rodents; leaves open translation to human HF.

Structured PICO

P
Population
Cardiac myocytes
I
Intervention
Activation of PKG I by NO/cGMP and adenoviral expression of PKG I
C
Comparator
Untreated cardiac myocytes or those expressing constitutively active calcineurin mutant
O
Outcome
Inhibition of calcineurin-NFAT signaling, BNP induction, and cell enlargementsurrogate

PKG I inhibits cardiac myocyte hypertrophy by targeting Ca2+-dependent steps upstream of calcineurin in the calcineurin-NFAT signaling pathway.

Cite This Study

Fiedler et al. (2002) studied this question.

synapsesocial.com/papers/6a10836d2badbc352a002bd7https://doi.org/10.1073/pnas.162100799
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