Why the study?
Does targeted genetic inhibition of calcineurin reduce cardiac hypertrophy in vivo in rodent models?
Population
Rodent models of cardiac hypertrophy (transgenic mice and adult rats)
Comparison
Genetic inhibition of calcineurin vs Control animals (implied)
Design
Preclinical
Authors
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Attenuates hypertrophy in rodent models; leaves open human translation and clinical relevance.
Does targeted genetic inhibition of calcineurin reduce cardiac hypertrophy in vivo in rodent models?
Targeted genetic inhibition of calcineurin attenuates cardiac hypertrophy in vivo, confirming its role as an important mediator of the hypertrophic response.
Windt et al. (2001) studied this question.
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