Why the study?
Does the calcineurin inhibitor FK506 attenuate the development and induce regression of cardiac hypertrophy in Dahl salt-sensitive rats?
Does the calcineurin inhibitor FK506 attenuate the development and induce regression of cardiac hypertrophy in Dahl salt-sensitive rats?
Inhibition of calcineurin with FK506 attenuates the development and induces regression of cardiac hypertrophy in a rat model of salt-sensitive hypertension.
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Does not support clinical use; hypothesis-generating for calcineurin inhibition in hypertensive hypertrophy and requires human trials.
Shimoyama et al. (2000) studied this question.
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