Why the study?
Does calcineurin inhibitor FK506 prevent the transition to heart failure and attenuate LV hypertrophy in hypertensive rats?
Does calcineurin inhibitor FK506 prevent the transition to heart failure and attenuate LV hypertrophy in hypertensive rats?
Calcineurin inhibition with FK506 attenuates LV hypertrophy and prevents heart failure in hypertensive rats only if started at the initial stage of pressure overload.
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Hypothesis-generating for early calcineurin inhibition in pressure-overload models; prospective human studies needed before clinical consideration.
Sakata et al. (2000) studied this question.
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