Key result
Myocardial calcineurin activity markedly increased in rats with exercise-induced LVH (46.4 vs 18.4 pmol/min/mg; P<0.001) and early pressure-overload LVH, but not in decompensated hypertrophy.
Why the study?
Does calcineurin participate in the signaling of exercise-induced physiological left ventricular hypertrophy in Wistar rats?
Population
Wistar rats
Comparison
10 weeks of voluntary exercise or ascending… vs Sedentary regimen or sham operation
Design
Preclinical
Follow-up
Up to 10 weeks
Authors
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Calcineurin may mediate exercise-induced LVH in rats; hypothesis-generating and should not yet change clinical practice.
Does calcineurin participate in the signaling of exercise-induced physiological left ventricular hypertrophy in Wistar rats?
Absolute Event Rate: 46.4% vs 18.4%
p-value: p=<0.001
Calcineurin is activated in exercise-induced physiological LVH and early pressure-overload LVH, and its inhibition by cyclosporin A blocks favorable adaptive hypertrophy.
Eto et al. (2000) studied Left ventricular hypertrophy. Voluntary exercise and aortic constriction vs. Sedentary regimen or sham operation was evaluated on Myocardial calcineurin activity (pmol. min(-1). mg(-1)) (p=<0.001). Myocardial calcineurin activity markedly increased in rats with exercise-induced LVH (46.4 vs 18.4 pmol/min/mg; P<0.001) and early pressure-overload LVH, but not in decompensated hypertrophy.
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