June 1, 2000AJP Heart and Circulatory Physiology
Cyclosporin A inhibits cardiac hypertrophy and enhances cardiac dysfunction during postinfarction failure in rats
Key result
Cyclosporin A substantially attenuated compensatory myocardial hypertrophy in rats with congestive heart failure (P<0.05), but led to increased left ventricular dilatation and reduced cardiac function.
Why the study?
Does cyclosporin A inhibit myocardial hypertrophy and affect cardiac remodeling in rats with postinfarction congestive heart failure?
Population
Rats with congestive heart failure (CHF) induced by left coronary artery ligation
Comparison
Cyclosporin A (CsA) for 14 days vs Vehicle for 14 days
Design
Preclinical, randomized
Follow-up
14 days
Authors
Discussion
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Implication
Calcineurin inhibition may blunt compensatory hypertrophy but worsen remodeling in experimental HF; leaves open human relevance.
Study Design
Type
RCT
Randomization
randomized
Structured PICO
Does cyclosporin A inhibit myocardial hypertrophy and affect cardiac remodeling in rats with postinfarction congestive heart failure?
P
Population
Rats with congestive heart failure induced by left coronary artery ligation, followed for 14 days.
I
Intervention
Cyclosporin A (CsA) for 14 days
C
Comparator
Vehicle for 14 days
O
Outcome
Myocardial hypertrophy (assessed by ventricular weight-to-tibial length ratios)surrogate
Main Result
p-value: p=<0.05
Inhibition of calcineurin by cyclosporin A attenuates compensatory myocardial hypertrophy but aggravates cardiac dysfunction and remodeling after myocardial infarction in rats.
Cite This Study
Øie et al. (2000) conducted an RCT in Congestive heart failure (CHF) post-myocardial infarction. Cyclosporin A (CsA) vs. Vehicle was evaluated on Myocardial hypertrophy assessed by ventricular weight-to-tibial length ratios (p=<0.05). Cyclosporin A substantially attenuated compensatory myocardial hypertrophy in rats with congestive heart failure (P<0.05), but led to increased left ventricular dilatation and reduced cardiac function.