Why the study?
Does calcineurin inhibition with cyclosporin A ameliorate structural, contractile, and electrophysiologic consequences of postinfarction remodeling in a rat model?
Population
Male Sprague-Dawley rats subjected to myocardial infarction via left anterior descending coronary artery…
Comparison
Cyclosporin A initiated 2 days before surgery… vs Post-MI without cyclosporin A
Design
Preclinical
Follow-up
30 days
Authors
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Should not change post-MI care; hypothesis-generating for calcineurin inhibition in human remodeling.
Does calcineurin inhibition with cyclosporin A ameliorate structural, contractile, and electrophysiologic consequences of postinfarction remodeling in a rat model?
Calcineurin inhibition with cyclosporin A partially ameliorates post-MI hypertrophy, diastolic dysfunction, and electrophysiologic remodeling in a rat model.
Deng et al. (2001) studied this question.
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