Why the study?
Does chronic exposure to cyclosporin A alter excitation-contraction coupling and twitch force development in rat cardiac trabeculae?
Population
Intact trabeculae isolated from myocardium of rats
Comparison
Cyclosporin A 15 mg/kg/day for 21 days vs Untreated rats
Design
Preclinical
Follow-up
21 days
Authors
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These rat data do not guide cyclosporin use in patients; leaves open whether similar calcium-handling changes occur in human myocardium.
Does chronic exposure to cyclosporin A alter excitation-contraction coupling and twitch force development in rat cardiac trabeculae?
Chronic cyclosporin A exposure alters calcium sensitivity and force development in rat myocardium, likely due to facilitated calcium release from the sarcoplasmic reticulum rather than changes in myofilament properties.
Bamjamali et al. (1993) studied this question.
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