May 1, 1991Transplantation

The Effect of Cyclosporine on Electrically Paced Isolated Rat Cardiomyocytes

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Why the study?

Does cyclosporine cause acute cardiotoxicity in isolated electrically paced adult rat cardiomyocytes?

Population

Isolated cardiomyocytes from adult rats

Comparison

Cyclosporine 1 to 10 micrograms/ml with… vs Drug vehicle methanol or pure Krebs Ringer Hepes…

Design

Preclinical

Follow-up

30 min

Authors

HOH. G. OlbrichAsklepios Klinik Langen HGHugo GeertsCertara (United States)UWU. WaldmannHokkaido University

Discussion

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Implication

Hypothesis-generating for cyclosporine cardiotoxicity in rat myocytes; leaves open clinical relevance in transplant patients.

Structured PICO

Does cyclosporine cause acute cardiotoxicity in isolated electrically paced adult rat cardiomyocytes?

Population

Isolated cardiomyocytes from adult rats

Intervention

Cyclosporine (CsA) 1 to 10 micrograms/ml with electrical-field stimulation

Comparator

Drug vehicle methanol or pure Krebs Ringer Hepes buffer

Outcome

Number of surviving rod-shaped myocytes and intracellular free calcium concentrationsurrogate

Cyclosporine exerts dose-dependent acute cardiotoxicity in isolated rat cardiomyocytes, likely mediated by increased intracellular free calcium concentration.

Cite This Study

Olbrich et al. (1991) studied this question.

synapsesocial.com/papers/6a883a59fc0635f4eccf0c2c https://doi.org/10.1097/00007890-199105000-00008

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The Effect of Cyclosporine on Electrically Paced Isolated Rat Cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Effect of Cyclosporine on Electrically Paced Isolated Rat Cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider