Why the study?
Does cyclosporin A affect contractile activity and cytoskeleton organization in chick embryo cardiomyocytes?
Population
Chick embryo cardiomyocytes grown as small aggregates or explants suspended on a network of elastic glass…
Design
Preclinical
Follow-up
20-24 h
Authors
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CsA alters chick cardiomyocyte contractility and cytoskeleton in vitro at therapeutic levels; leaves open relevance to human cardiotoxicity or clinical practice.
Does cyclosporin A affect contractile activity and cytoskeleton organization in chick embryo cardiomyocytes?
Cyclosporin A directly affects the contractile activity, morphology, and cytoskeleton architecture of heart cells in vitro.
Kołcz et al. (1999) studied this question.
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