Experimental model demonstrates dose-dependent impacts of Cyclosporine A on cardiomyocyte differentiation during cardiogenesis, highlighting mechanisms behind adverse effects.
Cyclosporine A (CsA) is a powerful immunosuppressive drug which significantly improved the success of organ transplantation; however, the major limiting factors for the drug's clinical use are its long and short term adverse effects. The present study was conducted to examine, in a dose-dependent manner, in a model of cardiogenesis, the effect of CsA on cardiomyocytes differentiation.
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Pâslaru et al. (2007) studied this question.
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