Why the study?
Does cyclosporine modulate single human cardiac L-type calcium channels in a Ca2+-dependent manner?
Population
Myocytes from human atrium and ventricle, and recombinant human embryonic kidney cells
Design
Preclinical
Authors
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Should not change clinical practice; hypothesis-generating for Ca2+-dependent LTCC regulation by cyclosporine.
Does cyclosporine modulate single human cardiac L-type calcium channels in a Ca2+-dependent manner?
Cyclosporine exerts a dual, Ca2+-dependent effect on human cardiac L-type calcium channels, highlighting the role of calcineurin in channel regulation.
Jan Matthes (2003) studied this question.
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