Why the study?
Does cyclosporin A improve left ventricular remodeling and pump dysfunction in mice post-myocardial infarction?
Population
C57BL/6 mice with induced myocardial infarction
Comparison
Cyclosporin A via gavage once daily starting 48… vs Vehicle via gavage once daily
Design
Preclinical, Randomized to either vehicle or CsA groups
Follow-up
7 or 28 days
Authors
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Cyclosporin A does not attenuate post-MI remodeling or dysfunction in mice; leaves open translation of apoptosis reduction to clinical benefit.
Does cyclosporin A improve left ventricular remodeling and pump dysfunction in mice post-myocardial infarction?
Although cyclosporin A reduces apoptosis late after myocardial infarction, it does not attenuate late left ventricular remodeling or pump dysfunction.
Kholmukhamedov et al. (2013) studied this question.
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