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March 28, 2008Circulation ResearchOpen Access

Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca 2+ Channel Regulation in Adult Rat Ventricular Myocytes

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Population

Adult rat ventricular myocytes (ARVMs)

Design

Preclinical

Authors

JLJérôme LeroyAAAniella Abi‐GergesVNViacheslav O. Nikolaev

Discussion

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Overview

No immediate clinical implications; leaves open whether PDE3/4 modulation can exploit cAMP compartmentalization in human cardiomyocytes.

Structured PICO

P
Population
Adult rat ventricular myocytes (ARVMs)
I
Intervention
Brief (15 seconds) pulses of isoprenaline (100 nmol/L) with or without phosphodiesterase (PDE) inhibitors (Ro 20-1724, cilostamide, 3-isobutyl-l-methylxanthine) or protein kinase inhibitor
O
Outcome
Time course of cAMP changes beneath the membrane and within the cytosol, and L-type Ca2+ channel current (I(Ca,L)) amplitudesurrogate

The study demonstrates temporally distinct beta-adrenergic receptor cAMP compartments in adult rat ventricular myocytes and clarifies the roles of PDE3 and PDE4 in regulating these signals.

Cite This Study

Leroy et al. (2008) studied this question.

synapsesocial.com/papers/6a828de025bcba1e23d4a287https://doi.org/10.1161/circresaha.107.167817
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling1997 · 103 citations
  2. 2Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following 2-adrenergic stimulation of ICa,L in frog ventricular myocytes2003 · 63 citations
  3. 3Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes2003 · 65 citations
  4. 4Characterization of the cyclic nucleotide phosphodiesterase subtypes involved in the regulation of the L‐type Ca<sup>2+</sup> current in rat ventricular myocytes1999 · 184 citations
  5. 5cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists.1996 · 375 citations