Russian Experience of the Rational Thromboprophylaxis in Traumatology and Orthopaedics

10,241 patients undergoing total knee or hip arthroplasty at Russian hospitals, receiving oral anticoagulants for 35 days to 6 weeks post-surgery.

Dabigatran etexilate 220 mg once daily, rivaroxaban 10 mg once daily, or apixaban 2.5 mg twice daily. Duration of treatment was 35 days after surgery for total hip arthroplasty and 6 weeks after surgery for total knee arthroplasty. All patients received additional thromboprophylaxis with intermittent compression device and compression stockings.

Active comparators: the three oral anticoagulants (dabigatran, rivaroxaban, apixaban) were compared against each other. All groups received background prophylaxis with intermittent compression devices and compression stockings.

Incidence of clinically significant deep vein thrombosis of the lower limbs (efficacy) and incidence of bleeding/postoperative hematomas in the postoperative period (safety).hard clinical