Key result
PPARγ acting within adipose progenitor cells controls the assembly and maintenance of the adipose vascular niche by transcriptionally activating PDGFRβ and VEGF.
Population
Mouse models and isolated adipose progenitor cells
Comparison
Genetic manipulation of PPARγ and… vs Wild-type/control mice or vehicle treatment
Design
Preclinical
Authors
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Provides a mechanistic link between adipogenesis and angiogenesis; leaves open whether targeting this progenitor-specific.
PPARγ acts within adipose progenitor cells to direct adipose tissue niche expansion via a PDGFRβ and VEGF transcriptional axis.
Jiang et al. (2017) studied Adipose tissue niche expansion. PPARγ activation/expression vs. PPARγ loss-of-function or vehicle was evaluated on Adipose vascular niche formation and APC niche interaction. PPARγ acting within adipose progenitor cells controls the assembly and maintenance of the adipose vascular niche by transcriptionally activating PDGFRβ and VEGF.
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