Preclinical study demonstrates 15-week vessel patency and aneurysm repair in animal models, highlighting the therapeutic potential of catheter-delivered nitinol grafts.
A new technique for percutaneous arterial grafting was developed using a unique metal alloy (nitinol) with a heat dependent memory. Ten tightly wound nitinol coils (5-15 mm in diameter and 2-5 cm in length) were straightened in ice water and passed via catheter into the iliac artery or abdominal aorta of nine animals. Long term patency (15 weeks) was demonstrated in all but one graft. In one animal, an experimentally created abdominal aortic aneurysm was successfully treated by interposition of a nitinol graft. This new technique may be a valuable adjunct to conventional treatment of both obstructive and aneurysmal arterial disease in man.
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Cragg et al. (1984) studied this question.
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