Synthesis, characterization and antimicrobial screening of substituted quiazolinones derivatives

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A series of new quinazolinone derivatives have been synthesized. Elemental analysis, IR, 1H NMR and mass spectral data elucidated the structures of all newly synthesized compounds. In vitro antimicrobial activities of the synthesized compounds were investigated against Gram-positive Bacillus subtilis (ATCC No. 6633), Staphylococcus aureus (ATCC No. 25923), Gram-negative Salmonella typhimurium (ATCC No. 23564), Pseudomonas aeruginosa (ATCC No. 27853) and fungi Candida albicans and Aspergillus niger. Among all the tested compounds, some of the tested compounds showed equipotent activity with standard.