Intradermal Tests and Antinuclear Factors in Systemic Lupus Erythematosus

Article1 December 1966Intradermal Tests and Antinuclear Factors in Systemic Lupus ErythematosusA Comparative StudyFARIS J. AZOURY, M.D., HENRY E. JONES, M.D., VINCENT J. DERBES, M.D., F.A.C.P., OREN B. GUM, M.D., PH.D.FARIS J. AZOURY, M.D.Search for more papers by this author, HENRY E. JONES, M.D.Search for more papers by this author, VINCENT J. DERBES, M.D., F.A.C.P.Search for more papers by this author, OREN B. GUM, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-6-1221 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAbnormal immunological reactions have been described more frequently and in greater number in systemic lupus erythematosus (SLE) than in any other disease. A wide variety of circulating antibodies that are capable of reacting with the patient's own tissues has been identified. Among these antibodies is a group that reacts with various nuclear components. Through the wide use of the immunofluorescent technique, the antinuclear factors (ANF) have been studied extensively by many investigators. However, to date very little has been done to correlate the presence of humoral antinuclear immunoglobulins and skin reactivity to nuclear antigens in SLE.Skin lesions are commonly...References1. DUBOISTUFFANELLI ELDL: Clinical manifestations of systemic lupus erythematosus. Computer analysis of 520 cases. JAMA 190: 104, 1964. CrossrefMedlineGoogle Scholar2. WATSONO'LEARYHARGRAVES JBPAMM: Neutrophils resembling LE cells in artificial blisters. Arch. Derm. (Chicago) 63: 328, 1951. CrossrefGoogle Scholar3. REBUCKBERMAN JWL: Experimental production of the LE phenomenon in the skin of man. Proc. Soc. Exp. Biol. Med. 75: 259, 1950. CrossrefMedlineGoogle Scholar4. PERILLIECALABRESIFINCH PEPSC: Demonstration of LE cells at local inflammatory sites in patients with systemic lupus erythematosus. New Eng. J. Med. 263: 1052, 1960. CrossrefMedlineGoogle Scholar5. WILSONABBOTTMILLER RMRRDK: The occurrence of LE cells and hematoxylin bodies in the naturally occurring cutaneous lesions of systemic lupus erythematosus. Amer. J. Med. Sci. 241: 31, 1961. CrossrefMedlineGoogle Scholar6. VERZTMANPAOLAGANDELMAN LDDL: 'Delayed cutaneous' hypersensitivity to leukocyte in patients with systemic lupus erythematosus (SLE). AIR 5: 498, 1962. Google Scholar7. FRIEDMANBARDAWILMERRILLHANAU EAWAJPC: "Delayed" cutaneous hypersensitivity to leukocytes in disseminated lupus erythematosus. New Eng. J. Med. 262: 486, 1960. CrossrefMedlineGoogle Scholar8. BENNETTHOLLEY JCHL: The use of cutaneous hypersensitivity to leukocytes in the diagnosis of disseminated lupus erythematosus, in Inflammation and Diseases of Connective Tissue, edited by MILLS, L. C., MOYER, J. H. W. B. Saunders Co., Philadelphia and London, 1961, p. 205. Google Scholar9. TROMOVITCHMARCH TAC: Intradermal tests with autologous white blood cells in chronic discoid lupus erythematosus, systemic lupus erythematosus and control subjects. J. Invest. Derm. 37: 345, 1961. CrossrefMedlineGoogle Scholar10. VACHTENHEIMSVOJITKA JJ: [The hypersensitive skin test in systemic lupus erythematosus] (Ger.). Allerg. Asthma (Leipzig) 8: 232, 1962. MedlineGoogle Scholar11. MANGANOTTISILVESTRI GU: [Research on intradermal reactions to leukocytes in the collagenoses and various dermatoses (preventive note)] (Ital.). Arch. Ital. Derm. Vener. 32: 142, 1963. MedlineGoogle Scholar12. CHIEREGATOFALDARINI GCG: Sull iniezioni intradermiche di autoleucociti e di acidi nucleic nell' eritematode. Minerva Derma. 39: 108, 1964. MedlineGoogle Scholar13. ORESLANGE ROK: Skin test for the diagnosis of systemic lupus erythematosus. Amer. J. Med. Sci. 248: 562, 1964. CrossrefMedlineGoogle Scholar14. FARDALWINKELMANN RWRK: Hypersensitivity to deoxyribonucleic acid in cutaneous disease. Arch. Derm. (Chicago) 91: 503, 1965. CrossrefMedlineGoogle Scholar15. LITTLEBELL ASHE: Painful subcutaneous hemorrhages of the extremities with unusual reaction to injected deoxyribonucleic acid. Ann. Intern. Med. 60: 886, 1964. LinkGoogle Scholar16. WALFORDPETERSONDOYLE RLETP: Leukocyte antibodies in human sera and in immune rabbit sera. Blood 12: 953, 1957. CrossrefMedlineGoogle Scholar17. MAUPIN B: Au sujet de la séparation des leukocytes du sang humain; un phénomène de sédimentation paradoxale. Sang 26: 328, 1955. MedlineGoogle Scholar18. WOLF-JÜRGENSENSCHWARTZ PM: Normal lymphocyte transfer in man. Basophil leukocytes in delayed skin reaction. Lancet 2: 388, 1964. CrossrefMedlineGoogle Scholar19. UHR JW: Delayed hypersensitivity in man, in Immunological Diseases, edited by SAMTER, M., ALEXANDER, H. L. Little, Brown and Co., Boston, 1965, p. 305. Google Scholar20. LACHMANNKUNKEL PJHG: Correlation of antinuclear antibodies and nuclear staining patterns. Lancet 2: 436, 1961. CrossrefMedlineGoogle Scholar21. CASALSFRIOUTEAGUE SPGJPO: Specific nuclear reaction pattern of antibody to DNA in lupus erythematosus sera. J. Lab. Clin. Med. 62: 625, 1963. MedlineGoogle Scholar22. FRIOU GJ: Immunofluorescence and antinuclear antibodies. Arthritis Rheum. 7: 161, 1964. CrossrefMedlineGoogle Scholar23. CASALSFRIOUMYERS SPGJLL: Significance of antibody to DNA in systemic lupus erythematosus. Ibid., p. 379. Google Scholar24. COHNHIRSCH ZAJG: The isolation and properties of the specific cytoplasmic granules of rabbit polymorphonuclear leukocytes. J. Exp. Med. 112: 983, 1960. CrossrefMedlineGoogle Scholar25. JANOFFZWEIFACH ABW: Adhesions and emigration of leukocytes produced by cationic proteins of lysosomes. Science 144: 1456 1964. CrossrefMedlineGoogle Scholar26. THOMAS L: Possible role of leukocyte granules in the Shwartzman and arthus reactions. Proc. Soc. Exp. Biol. Med. 115: 235, 1964. CrossrefMedlineGoogle Scholar27. BRENTMEDAWAR LPB: Tissue transplantation: a new approach to the "typing" problem. Brit. Med. J. 2: 269, 1963. CrossrefMedlineGoogle Scholar28. GRAYRUSSELL JGPS: Donor selection in human organ transplantation. A possible screening test. Lancet 2: 863, 1963. CrossrefMedlineGoogle Scholar29. HOLMAN HR: Systemic lupus erythematosus: a review of certain recent developments in the study of this disease. J. Pediat. 56: 109, 1960. CrossrefMedlineGoogle Scholar30. MERRILLFRIEDMANWILSONMARSHALL JPEAREDC: The production of "delayed type" cutaneous hypersensitivity to human donor leukocytes as a result of the rejection of skin homografts. J. Clin. Invest. 40: 631, 1961. CrossrefMedlineGoogle Scholar31. TROMOVITCHHARBERBAER TALCRL: The WBC skin test and LE cell test in systemic lupus erythematosus. Arch. Derm. (Chicago) 85: 374, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FARIS J. AZOURY, M.D.; HENRY E. JONES, M.D.; VINCENT J. DERBES, M.D., F.A.C.P.; OREN B. GUM, M.D., PH.D.Affiliations: New Orleans, Louisiana, and Detroit, MichiganFrom the Section of Arthritis, Department of Medicine, Section of Allergy and Dermatology, Department of Medicine, Tulane University School of Medicine, New Orleans, La., and the Section of Rheumatology, Department of Medicine, Wayne State University School of Medicine, Detroit, Mich.This work was supported in part by grant TI AM 5005, the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.This paper was presented in part at the Annual Meeting of the American Rheumatism Association, June 17, 1965, Philadelphia, Pa.Requests for reprints should be addressed to Faris J. Azoury, M.D., Department of Medicine, Wayne State University School of Medicine, 1400 Chrysler Freeway, Detroit, Mich. 48207. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDNA Skin Tests in Patients with Definite or Suspected Systemic Lupus Erythematosus and in Dermatological Control Patients A Long-term Follow-up StudyStudies of the Effects of Y Chromosome Factors on the Expression of Autoimmune DiseaseImmune Response Potential and Its Genetic Regulation in Autoimmune Diseases Alterations in Systemic Lupus Erythematosus and Thyroid Autoimmune DiseasesAntinucleic Acid Antibodies, Gene Expression, and Autoimmune MiceBlood and tissue analysis of T-cell subsets in cutaneous diseasesImmunity in Systemic Lupus ErythematosusCell-Mediated Immunity in Systemic Lupus ErythematosusThe deoxyribonucleic acid (DNA) skin test in systemic lupus erythematosus.Cellular immunity in systemic lupus erythematosusCell-mediated immune response in systemic lupus erythematosus.Abnormalities of delayed hypersensitivity in systemic lupus erythematosusThe peripheral blood leukocyte migration inhibition test in systemic lupus erythematosusImmunological Reactivity in Patients with Systemic Lupus Erythematosus: Humoral Antibody and Cellular Immune ResponsesLE CELLS IN BIOPSIES OF POSITIVE DEOXYRIBONUCLEIC ACID SKIN TESTSDelayed hypersensitivity in systemic lupus erythematosus. 1 December 1966Volume 65, Issue 6Page: 1221-1228KeywordsAntibodiesAntigensArthritisAtrial natriuretic peptidesDermatologyLesionsLupus erythematosusMetabolic disordersRheumatologySystemic lupus erythematosus ePublished: 1 December 2008 Issue Published: 1 December 1966 PDF downloadLoading ...