Key result
Shen-Fu injection attenuated postresuscitation myocardial dysfunction, improving left ventricular function and energy metabolism compared to placebo in a porcine model of cardiac arrest.
Why the study?
Does Shen-Fu injection improve postresuscitation myocardial dysfunction in a porcine model of cardiac arrest?
RCT (n=16)
placebo-controlled
randomized
Does Shen-Fu injection improve postresuscitation myocardial dysfunction in a porcine model of cardiac arrest?
Shen-Fu injection attenuates postresuscitation myocardial dysfunction and improves hemodynamics in a porcine model of cardiac arrest, likely through beneficial effects on energy metabolism and antioxidant capacity.
Hypothesis-generating in porcine cardiac arrest; leaves open translation to human postresuscitation myocardial recovery.
To investigate the effect of Shen-Fu injection (SFI) for the management of postresuscitation myocardial dysfunction in a porcine model of cardiac arrest. Ventricular fibrillation was induced electrically in anesthetized domestic swine. After 4 min of untreated ventricular fibrillation, cardiopulmonary resuscitation was initiated. Sixteen successfully resuscitated pigs were randomized to receive a continuous infusion of either SFI (0.24 mg/min) or saline placebo for 6 h, beginning 15 min after return of spontaneous circulation (ROSC). The SFI treatment produced better left ventricular +dP/dtmax, -dP/dtmax, cardiac output, and ejection fraction after ROSC. The SFI treatment also produced lower serum cardiac troponin I, lactate levels, and left ventricle malondialdehyde content after ROSC, whereas left ventricle superoxide dismutase, Na-K-ATPase, and Ca-ATPase activity were significantly increased in the SFI group when compared with saline group. The cardioprotective effect of SFI was further confirmed by myocardial ultrastructure examination. Shen-Fu injection can attenuate postresuscitation myocardial dysfunction through beneficial effects on energy metabolism and remarkable antioxidant capacity.
No takes yet. Share an insight, caveat, or question.
Ji et al. (2011) conducted an RCT in Cardiac arrest with postresuscitation myocardial dysfunction (n=16). Shen-Fu injection vs. saline placebo was evaluated on Postresuscitation myocardial dysfunction (left ventricular +dP/dtmax, -dP/dtmax, cardiac output, and ejection fraction). Shen-Fu injection attenuated postresuscitation myocardial dysfunction, improving left ventricular function and energy metabolism compared to placebo in a porcine model of cardiac arrest.