Key result
A parental history of sudden cardiac arrest was independently associated with an increased risk of sudden cardiac arrest (AOR 2.51), alongside low education, heart disease, smoking, and non-regular exercise.
Why the study?
Genetic, environmental, and behavioral factors play a role in sudden cardiac arrest, but the strength of the association between various risk factors and SCA incidence needed to be determined.
Do genetic, socioeconomic, and behavioral risk factors increase the incidence of sudden cardiac arrest in adults?
Case-Control (n=1,896)
Yes
Do genetic, socioeconomic, and behavioral risk factors increase the incidence of sudden cardiac arrest in adults?
Odds Ratio: 2.51 (95% CI 1.48–4.28)
Absolute Event Rate: 6.8% vs 2.6%
p-value: p=<0.001
Various genetic, socioeconomic, and behavioral risk factors are independently associated with an increased risk of sudden cardiac arrest, highlighting the need for individualized prevention strategies.
May guide SCA risk stratification; leaves open whether targeting these factors reduces incidence.
Genetic, environment, and behaviour factors have a role in causing sudden cardiac arrest (SCA). We aimed to determine the strength of the association between various risk factors and SCA incidence. We conducted a multicentre case-control study at 17 hospitals in Korea from September 2017 to December 2020. The cases included out-of-hospital cardiac arrest aged 19-79 years with presumed cardiac aetiology. Community-based controls were recruited at a 1:1 ratio after matching for age, sex, and urban residence level. Multivariable conditional logistic regression analysis was conducted. Among the 1016 cases and 1731 controls, 948 cases and 948 controls were analysed. A parental history of SCA, low educational level, own heart disease, current smoking, and non-regular exercise were associated with SCA incidence (Adjusted odds ratio [95% confidence interval]: 2.51 [1.48-4.28] for parental history of SCA, 1.37 [1.38-2.25] for low edication level, 3.77 [2.38-5.90] for non-coronary artery heart disease, 4.47 [2.84-7.03] for coronary artery disease, 1.39 [1.08-1.79] for current smoking, and 4.06 [3.29-5.02] for non-regular exercise). Various risk factors related to genetics, environment, and behaviour were independently associated with the incidence of SCA. Establishing individualised SCA prevention strategies in addition to general prevention strategies is warranted.
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Jung et al. (2023) conducted a case-control in Sudden cardiac arrest (n=1,896). Parental history of sudden cardiac arrest vs. No parental history of sudden cardiac arrest was evaluated on Incidence of sudden cardiac arrest (AOR 2.51, 95% CI 1.48-4.28, p=<0.001). A parental history of sudden cardiac arrest was independently associated with an increased risk of sudden cardiac arrest (AOR 2.51), alongside low education, heart disease, smoking, and non-regular exercise.
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