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February 1, 1983Proceedings of the National Academy of SciencesOpen Access

Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis.

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Authors

MAMary E. AndersonUniversity of IowaAMA MeisterMerck & Co., Inc., Rahway, NJ, USA (United States)

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Anderson et al. (1983) studied this question.

synapsesocial.com/papers/6a83092ec009eb9b7eefdfb2https://doi.org/10.1073/pnas.80.3.707
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Translocation of intracellular glutathione to membrane-bound γ-glutamyl transpeptidase as a discrete step in the γ-glutamyl cycle: Glutathionuria after inhibition of transpeptidase1979 · 248 citations
  2. 2Excretion of cysteine and gamma-glutamylcysteine moieties in human and experimental animal gamma-glutamyl transpeptidase deficiency.1980 · 127 citations
  3. 3Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation.1981 · 230 citations
  4. 4Glutathione: interorgan translocation, turnover, and metabolism.1979 · 609 citations
  5. 5Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).1979 · 1,698 citations