Population
Rat juxtamedullary afferent arterioles (n=41) pretreated with enalaprilat (2 mg i.v.)
Comparison
Purinergic stimulation with 2-chloroadenosine… vs Control conditions (baseline)
Design
Preclinical
Authors
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May inform purinergic control of renal arterioles; leaves open human relevance in hypertension.
Rat juxtamedullary afferent arterioles possess both adenosine-sensitive P1 and ATP-sensitive P2 purinergic receptors, with ATP directly inducing vasoconstriction.
Inscho et al. (1991) studied this question.
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