Answers are grounded in this paper and cite their sources.
License to degrade. A chimeric small molecule or PROTAC (PROteolysis TArgeting Chimera) based on the chemopreventive natural product apigenin was developed (see scheme). The molecule was shown to target the aryl hydrocarbon receptor (AHR) for degradation by the proteasome.
No takes yet. Share an insight, caveat, or question.
Lee et al. (2007) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: