What is the clinical evidence from this study?

Study design: Cohort. Population: Ischaemic stroke (n=26960). Intervention: Atrial fibrillation vs. No atrial fibrillation. Primary outcome: 90-day mortality (adjusted for age and co-morbidities) (p=<0.0001).

What question did this study set out to answer?

To assess the clinical burden, mortality rates, and healthcare utilization in patients presenting with ischaemic stroke complicated by atrial fibrillation.

January 1, 2011Cerebrovascular Diseases

Outcomes for Patients with Ischaemic Stroke and Atrial Fibrillation: The PRISM Study (A Program of Research Informing Stroke Management)

Q: What are the key findings of this study?

Atrial fibrillation in patients with ischaemic stroke was associated with significantly higher 90-day adjusted mortality compared to those without AF (20.9% vs 14.7%, P<0.0001).

Q: What question did this study set out to answer?

To assess the clinical burden, mortality rates, and healthcare utilization in patients presenting with ischaemic stroke complicated by atrial fibrillation.

View Full Paper

Ask AI

Bookmark

Key result

Atrial fibrillation in patients with ischaemic stroke was associated with significantly higher 90-day adjusted mortality compared to those without AF (20.9% vs 14.7%, P<0.0001).

Why the study?

Does atrial fibrillation worsen mortality and hospital outcomes in patients with ischaemic stroke?

Population

26,960 patients aged 18+ years with a primary or stay diagnosis of ischaemic stroke in New South Wales…

Comparison

Presence of atrial fibrillation recorded during… vs Absence of atrial fibrillation (non-AF)

Design

Cohort

Follow-up

Up to 365 days for mortality

Authors

MGMelina GattellariRoyal Prince Alfred Hospital CGChris GoumasThe University of Sydney RAR. John AitkenLeiden University

Discussion

Member takes

Implication

AF associated with higher post-stroke mortality; extends observational data but leaves open whether targeted interventions improve outcomes.

Key Points

To assess the clinical burden, mortality rates, and healthcare utilization in patients presenting with ischaemic stroke complicated by atrial fibrillation.
Analyzed administrative hospital records in New South Wales across 26,960 patients aged 18+ years hospitalized with ischaemic stroke between July 2000 and June 2006.
Tracked mortality outcomes through December 2007, evaluating 30-day, 90-day, and 1-year mortality, hospital length of stay, and rehabilitation service access.
Atrial fibrillation occurred in 25.4% of stroke cases and was associated with significantly higher unadjusted mortality at 30 days (19.4% vs. 11.5%), 90 days (27.7% vs. 15.8%), and 365 days (38.5% vs. 22.6%; p < 0.0001 for all).
Adjusted 90-day mortality remained elevated in atrial fibrillation cases (20.9% vs. 14.7%; p < 0.0001), with the highest 30-day relative risk observed in patients under 50 years of age (RR 3.16; 95% CI 1.92–5.25) compared to those aged 85+ (RR 1.23; 95% CI 1.13–1.33).
Surviving patients with atrial fibrillation experienced longer median hospital stays (19.2 vs. 14.5 days; p < 0.001) and utilized in-hospital rehabilitation more frequently (36.6% vs. 31.8%; p < 0.0001).

Study Design

Type

Cohort (n=26,960)

Multicenter

Yes

Structured PICO

Does atrial fibrillation worsen mortality and hospital outcomes in patients with ischaemic stroke?

Population

26,960 patients aged ≥18 years hospitalized with ischaemic stroke in New South Wales between 2000 and 2006, followed for mortality up to December 2007.

Exposure

Presence of atrial fibrillation (AF) recorded during admission

Comparator

Absence of atrial fibrillation (non-AF)

Outcome

Mortality at 30, 90, and 365 dayshard clinical

Main Result

Absolute Event Rate: 20.9% vs 14.7%

p-value: p=<0.0001

Ischaemic stroke patients with AF have substantially worse mortality and longer hospital stays than those without AF, with the relative impact of AF being most pronounced in younger patients.

Cite This Study

Gattellari et al. (2011) conducted a cohort in Ischaemic stroke (n=26,960). Atrial fibrillation vs. No atrial fibrillation was evaluated on 90-day mortality (adjusted for age and co-morbidities) (p=<0.0001). Atrial fibrillation in patients with ischaemic stroke was associated with significantly higher 90-day adjusted mortality compared to those without AF (20.9% vs 14.7%, P<0.0001).

synapsesocial.com/papers/6a830979a353bb944193c6ec https://doi.org/10.1159/000330637

Topics

Atrial fibrillation Persistent AF management Anticoagulation in AF AF ablation outcomes

View Full Paper

Ask AI

Bookmark

Implication

AF associated with higher post-stroke mortality; extends observational data but leaves open whether targeted interventions improve outcomes.

Outcomes for Patients with Ischaemic Stroke and Atrial Fibrillation: The PRISM Study (A Program of Research Informing Stroke Management)

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Outcomes for Patients with Ischaemic Stroke and Atrial Fibrillation: The PRISM Study (A Program of Research Informing Stroke Management)

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider