What question did this study set out to answer?

To characterize a novel human retrovirus isolated from a patient with a T-cell variant of hairy cell leukemia and assess its relationship to known human T-cell leukemia virus isolates.

November 5, 1982Science

A New Subtype of Human T-Cell Leukemia Virus (HTLV-II) Associated with a T-Cell Variant of Hairy Cell Leukemia

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Authors

VKV. S. Kalyanaraman MSM. G. SarngadharanUniversity of North Carolina at Chapel Hill MRMarjorie Robert-GuroffNational Cancer Institute

Discussion

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Overview

Virological analysis uncovers a novel retrovirus subtype in a hairy cell leukemia variant, indicating distinct immunological classes among human T-cell leukemia viruses.

Key Points

To characterize a novel human retrovirus isolated from a patient with a T-cell variant of hairy cell leukemia and assess its relationship to known human T-cell leukemia virus isolates.
Assayed serum from a patient (Mo) presenting with a T-cell variant of hairy cell leukemia for antibodies against the HTLV major internal core protein (p24).
Established a splenic T-cell line from the patient to evaluate HTLV antigen expression.
Performed immunological cross-reactivity assays on the p24 core protein to compare the isolate with prototype HTLV strains.
Mo serum demonstrated specific antibodies against the HTLV p24 core protein, and the spleen-derived T-cell line actively expressed HTLV antigens.
Immunological cross-reactivity tests demonstrated that the p24 core protein was significantly distinct from previously known prototype isolates (HTLV-I), establishing a separate subtype designated HTLV-II.

Cite This Study

Kalyanaraman et al. (1982) studied this question.

synapsesocial.com/papers/6a8309c1a250d11ff44cd134 https://doi.org/10.1126/science.6981847

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November 5, 1982Science

A New Subtype of Human T-Cell Leukemia Virus (HTLV-II) Associated with a T-Cell Variant of Hairy Cell Leukemia

View Full Paper

Ask AI

Bookmark

Authors

VKV. S. Kalyanaraman MSM. G. SarngadharanUniversity of North Carolina at Chapel Hill MRMarjorie Robert-GuroffNational Cancer Institute

Discussion

Member takes

Overview

Virological analysis uncovers a novel retrovirus subtype in a hairy cell leukemia variant, indicating distinct immunological classes among human T-cell leukemia viruses.

Key Points

To characterize a novel human retrovirus isolated from a patient with a T-cell variant of hairy cell leukemia and assess its relationship to known human T-cell leukemia virus isolates.
Assayed serum from a patient (Mo) presenting with a T-cell variant of hairy cell leukemia for antibodies against the HTLV major internal core protein (p24).
Established a splenic T-cell line from the patient to evaluate HTLV antigen expression.
Performed immunological cross-reactivity assays on the p24 core protein to compare the isolate with prototype HTLV strains.
Mo serum demonstrated specific antibodies against the HTLV p24 core protein, and the spleen-derived T-cell line actively expressed HTLV antigens.
Immunological cross-reactivity tests demonstrated that the p24 core protein was significantly distinct from previously known prototype isolates (HTLV-I), establishing a separate subtype designated HTLV-II.

Cite This Study

Kalyanaraman et al. (1982) studied this question.

synapsesocial.com/papers/6a8309c1a250d11ff44cd134 https://doi.org/10.1126/science.6981847

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