Key result
Serum WISP1 and betatrophin levels were elevated in women with PCOS compared to controls, with the highest levels observed in the obese PCOS subgroup.
Why the study?
Are serum WISP1 and betatrophin levels elevated in women with PCOS compared to healthy controls, and how do they relate to metabolic and atherogenic profiles?
Cross-Sectional (n=145)
Are serum WISP1 and betatrophin levels elevated in women with PCOS compared to healthy controls, and how do they relate to metabolic and atherogenic profiles?
WISP1 and betatrophin levels are elevated in women with PCOS, particularly those with obesity, and correlate with metabolic and hormonal markers such as HOMA-IR and AMH.
May support biomarker exploration in obese PCOS; hypothesis-generating and should not yet change practice.
OBJECTIVE: To determine the levels of WISP1 and betatrophin in normal weight and obese women with polycystic ovary syndrome (PCOS) and to assess their relationship with anti-Müllerian hormone (AMH) levels, atherogenic profile and metabolic parameters Methods: In this prospective cross-sectional study, the study group was composed of 49 normal weighed and 34 obese women with PCOS diagnosed based on the Rotterdam criteria; 36 normal weight and 26 obese age matched non-hyperandrogenemic women with regular menstrual cycle. Serum WISP1, betatrophin, homeostasis model assessment of insulin resistance (HOMA-IR) and AMH levels were evaluated. Univariate and multivariate analyses were performed between betatrophin, WISP1 levels and AMH levels, metabolic and atherogenic parameters. RESULTS: Serum WISP1 and betatrophin values were elevated in the PCOS group than in the control group. Moreover, serum WISP1 and betatrophin levels were higher in the obese PCOS subgroup than in normal weight and obese control subgroups. Multivariate analyses revealed that Body mass index, HOMA-IR, AMH independently and positively predicted WISP1 levels. Serum betatrophin level variability was explained by homocysteine, HOMA-IR and androstenedione levels. CONCLUSION: WISP1 and betatrophin may play a key role on the pathogenesis of PCOS.
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Ersoy et al. (2016) conducted a cross-sectional in Polycystic ovary syndrome (PCOS) (n=145). Polycystic ovary syndrome (PCOS) vs. Age-matched non-hyperandrogenemic women with regular menstrual cycles was evaluated on Serum WISP1 and betatrophin levels. Serum WISP1 and betatrophin levels were elevated in women with PCOS compared to controls, with the highest levels observed in the obese PCOS subgroup.
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