What question did this study set out to answer?

To determine whether IL-12Rβ2 expression on recipient nonhematopoietic cells is required for the development and severity of gastrointestinal acute graft-versus-host disease following allogeneic hematopoietic cell transplantation.

December 21, 2022The Journal of ImmunologyOpen Access

The Absence of IL-12Rβ2 Expression on Recipient Nonhematopoietic Cells Diminishes Acute Graft-versus-Host Disease in the Gastrointestinal Tract

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To determine whether IL-12Rβ2 expression on recipient nonhematopoietic cells is required for the development and severity of gastrointestinal acute graft-versus-host disease following allogeneic hematopoietic cell transplantation.
Evaluated acute graft-versus-host disease progression in murine models of allogeneic hematopoietic cell transplantation using genetic depletion of IL-12R signaling.
Assessed intestinal barrier integrity, MHC class II expression by intestinal epithelial cells, and IL-12Rβ2 expression profiles on activated T cells and gastrointestinal tissues.
Genetic depletion of IL-12Rβ2 on recipient nonhematopoietic cells significantly reduced the severity of acute graft-versus-host disease in the gastrointestinal tract.
Disease attenuation was accompanied by decreased MHC class II expression on intestinal epithelial cells and the preservation of intestinal mucosal integrity.

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Implication

Preclinical study reveals attenuated gastrointestinal acute graft-versus-host disease in IL-12Rβ2-deficient mice, indicating nonhematopoietic receptors as potential therapeutic targets.

Cite This Study

Bastian et al. (2022) studied this question.

synapsesocial.com/papers/6a830a69f568d6f39593c72b https://doi.org/10.4049/jimmunol.2200120

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Implication

Preclinical study reveals attenuated gastrointestinal acute graft-versus-host disease in IL-12Rβ2-deficient mice, indicating nonhematopoietic receptors as potential therapeutic targets.

The Absence of IL-12Rβ2 Expression on Recipient Nonhematopoietic Cells Diminishes Acute Graft-versus-Host Disease in the Gastrointestinal Tract

Key Points

Discussion

Implication

Cite This Study

The Absence of IL-12Rβ2 Expression on Recipient Nonhematopoietic Cells Diminishes Acute Graft-versus-Host Disease in the Gastrointestinal Tract

Key Points

Discussion

Implication

Cite This Study

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