Key result
Left ventricular non-compaction exhibits high clinical and genetic variability, suggesting it may be a morphological expression of various cardiac diseases rather than a distinct cardiomyopathy.
Why the study?
The clinical profile, prognosis, and diagnosis of left ventricular non-compaction remain a major challenge, and its population prevalence is still unknown.
This review highlights the genetic heterogeneity and diagnostic challenges of LVNC, questioning its status as an independent cardiomyopathy and emphasizing its overlap with other cardiac phenotypes.
This review highlights and discusses recent advances in understanding left ventricular non - compaction (LVNC). Clinical profile, prognosis and even diagnosis are still a great challenge faced by the world. The population prevalence of left ventricular non - compaction remains unknown. High variability of clinical manifestations, genetic heterogenity with overlap of different phenotypes, variability of hereditary patterns suggests that LVNC seems to be rather an isolated trait or a part of phenotypic expression of different cardiac diseases or complex genetic syndromes.
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Streltsova et al. (2019) conducted a review in Left ventricular non-compaction (LVNC). Left ventricular non-compaction exhibits high clinical and genetic variability, suggesting it may be a morphological expression of various cardiac diseases rather than a distinct cardiomyopathy.
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