What question did this study set out to answer?

To determine whether interleukin-10 mediates clinical, cellular, and humoral tolerance during allergen immunotherapy for seasonal grass pollen allergy.

March 1, 2004The Journal of Immunology

Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL-10 Responses and Blocking IgG Activity

View Full Paper

Ask AI

Bookmark

To determine whether interleukin-10 mediates clinical, cellular, and humoral tolerance during allergen immunotherapy for seasonal grass pollen allergy.
Conducted a double-blind trial evaluating grass pollen (Phleum pratense) immunotherapy versus placebo alongside healthy control comparisons over a two-year duration.
Assessed local nasal mucosal IL-10 mRNA and protein expression, peripheral T-cell responses, and allergen-specific antibody titers before and after treatment.
Two years of immunotherapy induced nasal mucosal IL-10 mRNA and protein expression during pollen season, localized to CD68(+) macrophages (35%) and CD3(+) T cells (15%), with no changes in placebo recipients or healthy controls.
Immunotherapy blunted seasonal spikes in Phl p 5-specific IgE while triggering a 60- to 80-fold increase in Phl p 5-specific IgG and a 100-fold increase in Phl p 5-specific IgG4.
Post-treatment serum exhibited IgG4-associated inhibitory activity that blocked IgE-facilitated allergen binding to B cells and correlated with clinical symptom improvement.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Double-blind trial reveals mucosal IL-10 induction and protective blocking IgG4 activity in seasonal pollinosis, indicating an IL-10-dependent mechanism driving allergen tolerance.

Cite This Study

Nouri‐Aria et al. (2004) studied this question.

synapsesocial.com/papers/6a830ac467735c513e7d5d31 https://doi.org/10.4049/jimmunol.172.5.3252

View Full Paper

Ask AI

Bookmark

Implication

Double-blind trial reveals mucosal IL-10 induction and protective blocking IgG4 activity in seasonal pollinosis, indicating an IL-10-dependent mechanism driving allergen tolerance.

Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL-10 Responses and Blocking IgG Activity

Key Points

Discussion

Implication

Cite This Study

Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL-10 Responses and Blocking IgG Activity

Key Points

Discussion

Implication

Cite This Study

Keep reading

Keep reading