A new series of N ‐substituted‐3‐[1‐alkyl(aryl)‐4‐piperidyl]azetidin‐2‐ones 2a‐j structurally related to the previously reported 2,7‐diazaspiro[3.5]nonan‐1‐ones 1 have been synthesized and tested for their activity as muscarinic agents, both in vitro and in vivo . Preliminary pharmacological results showed that compounds 2 are devoid of significant cholinergic properties.
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Cignarella et al. (1993) studied this question.
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