An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed alpha-arylation of ketone enolates with aryl halides to install an all-carbon quaternary stereogenic center in up to 98% ee and excellent yields.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: