Specific binding of arginine to TAR RNA.

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Population

in vitro-transcribed 31-nucleotide TAR RNA and mutant TAR RNAs

Design

Preclinical

Authors

Discussion

L-arginine's selective TAR binding informs RNA-ligand design; leaves open translation to cellular or in vivo HIV models.

Population

in vitro-transcribed 31-nucleotide TAR RNA and mutant TAR RNAs

Intervention

L-arginine, L-lysine, and L-arginine analogs

Outcome

Binding inhibition (Ki) and specific binding to TAR RNAsurrogate

L-arginine specifically binds to TAR RNA at the same site as the Tat peptide, emphasizing the role of RNA structure in RNA-protein recognition.

Tao et al. (1992) studied this question.

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